Access
Road geometry, drive approach, turning/staging room, seasonal conditions, delivery size, and equipment access can influence both design and construction sequence.
Slope + earthwork
Slope can change foundation/retaining strategy, drainage, excavation, temporary access, safety planning, and how the building meets the landscape. Professional geotechnical/structural/civil input may be required; the builder should identify the need rather than replace it.
Utilities
Long runs, service availability, well/septic or other site-specific infrastructure, trenching/access, and coordination can become early budget/schedule drivers on rural sites.
Staging + logistics
A tight lot can have plenty of buildable area and almost no room to stage materials. Crane/lift needs, storage, waste handling, temporary protection, and just-in-time deliveries may change the sequence.
Design response
The best response is not always to fight the lot into behaving like a flat suburban parcel. Building placement, massing, courtyard, circulation, material choices, and landscape relationship can reduce some constraints while embracing others.
Questions before commitment
What site information exists? What has not been surveyed/tested? How does access work in winter? Where are utilities? What work area remains after the building footprint? Which site assumptions are already embedded in the purchase/design decision?